First funded by the National Cancer Institute in 1984, the Fred & Pamela Buffett Cancer Center is the only NCI-designated cancer center in Nebraska.

Formerly the Eppley Cancer Center, the Fred & Pamela Buffett Cancer Center was established by the University of Nebraska Board of Regents to coordinate all cancer research activities across the entire university. While the core of the cancer research activities of the Cancer Center is based on the UNMC campus in Omaha, the cancer center also has members at the University of Nebraska Lincoln and the University of Nebraska at Omaha.

Although the Fred & Pamela Buffett Cancer Center is a matrix cancer center organization, the director of the Fred & Pamela Buffett Cancer Center also serves as the Director of the Eppley Institute for Research in Cancer, an academic unit of UNMC with primary faculty appointments. The director has authority over the annual state budget for the cancer center and Eppley Institute, over all laboratory and clinical research space assigned to the cancer center, and over philanthropic funds raised by the cancer center.

The Cancer Center is devoted to excellence in cancer research through basic discovery, clinical/translational research, and research in cancer control and prevention. The cancer center is also committed to graduate and postgraduate education in cancer research and coordinates the federally funded training programs in cancer research, as well as oversees the Cancer Research Graduate Program (CRGP) doctoral degree granting program in cancer research at UNMC.

First funded by the NCI Cancer Center Support Grant 30 years ago, the Fred & Pamela Buffett Cancer Center has been continuously funded ever since and has a large regional responsibility with a patient catchment area that includes western Iowa, eastern South Dakota, northeastern Kansas and northwestern Missouri, in addition to Nebraska.

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